Instructions for UI:
Place the contents of the ZStartup folder into your C:\Program Files (x86)\Pixologic\ZBrush 4R5 FL\ZStartup folder.
Then go to Preferences/Config/Load UI, and browse to the ShanesCustomUserInterface4R5.cfg file that is included with this download and load it. If you like this new UI, select Preferences/Config/Store Config to make it your default interface.
kamilen1990