The Scientist 2018 01.pdf

(14851 KB) Pobierz
JANUARY 2018 | WWW.THE-SCIENTIST.COM
SODIUM
CHANNELS
AS TARGETS
FOR PAIN
RELIEF
THE HUNT FOR
ANALGESICS
IN ANIMAL TOXINS
DEVELOPING
SAFER OPIOIDS
The Science
of Pain
CAN SWEARING
HELP EASE PAIN?
PLUS
NEW RESEARCH ON
AN AGE-OLD AILMENT
Coming to SLAS 2018
The New Sound of Sample Management
Visit us at SLAS 2018 (San Diego) and learn how the newest development in sample management assures sample integrity, improves
data quality, and reduces running costs throughout the process. In collaboration with Brooks Life Science Systems, Titian Software, and
AstraZeneca, Labcyte is introducing the Access™ Dual Robot System (DRS) for sample management, seamlessly integrating Echo® Liquid
Handlers and acoustic tubes to eliminate the need for working plate libraries. The simplified process supports miniaturization starting
at sample storage, avoids the impact of microplate freeze-thaw cycles, eliminates the need for tip-based liquid handling, and improves
overall reliability of sample management workflows.
For more information, visit www.labcyte.com/slas2018.
© 2018 LABCYTE INC.
All rights reserved. Labcyte®, Echo®, and the Labcyte logo are
registered trademarks or trademarks of Labcyte Inc., in the U.S. and/or other countries.
2nd ANNUAL
SEPTEMBER 17-19, 2018
Reston, VA
Hyatt Regency Reston
Go to tsxpo.com
to receive updates by email.
Cell and Gene Therapy:
From Plate to Patient
3.
Congratulations to all of our 2017 winners!
To read the full article, please visit
the-scientist.com/2017Top10
8.
9.
7.
2.
5.
6.
10.
1.
IsoPlexis
IsoCode Chip
2. Abbott
i-STAT Alinity
3. QGel
QGel Assay Kit for Organoids
4. Intabio
Blaze
5. Quanterix
SR-X Ultra-Sensitive Biomarker
Detection System
6. Promega
HiBiT Protein Tagging System
7.
Dharmacon,
A Horizon Discovery
Group Company
Edit-R crRNA Library—
Human Genome
4.
8. 10x Genomics
Chromium
9. Thermo Fisher Scientific
TSQ Altis Triple Stage Mass Spectrometer
10. Thermo Fisher Scientific
Invitrogen TrueCut Cas9 Protein v2
1.
JANUARY 2018
Contents
THE SCIENTIST
THE-SCIENTIST.COM
VOLUME 32 NUMBER 1
© ISTOCK.COM/KTSIMAGE; © BETHLEM MUSEUM OF THE MIND, BECKENHAM, KENT/BRIDGEMAN IMAGES; © MATTHIJS KUIJPERS/ALAMY STOCK PHOTO
Features
ON THE COVER: © ISTOCK.COM/WUNDERVISUALS
26
Channeling the Pain
The race to develop analgesic drugs
that inhibit sodium channel Na
V
1.7
is revealing a complex sensory role
for the protein.
BY CATHERINE OFFORD
34
Glia and Pain
Immune-like cells in the central
nervous system are now recognized
as key participants in the creation
and maintenance of persistent pain.
BY MARK R. HUTCHINSON
42
Animal Analgesics
A cornucopia of toxins in the animal
kingdom could provide inspiration
for novel painkillers, but so far,
effective drugs have proven elusive.
BY
THE SCIENTIST
STAFF
01 .2 01 8 | T H E S C IEN T IST
3

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin