The Scientist 2018 06.pdf

(14232 KB) Pobierz
JUNE 2018 | WWW.THE-SCIENTIST.COM
MICROBIAL
TREASURE
NEWLY DISCOVERED ARCHAEA
REVEAL BIZARRE BIOLOGY
WHEN PATHOGENS
JUMP TO HUMANS
CAVEOLAE STEP
INTO THE LIGHT
LIFE SCIENCE
IN THE CLOUD
GENOMICS
AND RACE
PLUS
Copyright © 2018 PerkinElmer, Inc. 400378A_06 All rights reserved. PerkinElmer
®
is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners.
UNDERSTANDING STARTS
WHEN YOU PUT
COMPLEXITY INTO CONTEXT
PHENOPTICS
SOLUTIONS
Opal
Multiplex Staining
Vectra
®
3 and Vectra
®
Polaris
Multiplex Biomarker Imaging Systems
inForm
®
Image Analysis Software
Our bodies’ natural disease-fighting capabilities just might lead to
new cancer therapy strategies
Many different cell types contribute to tumor growth. But phenotyping cells while maintaining
cellular spatial relationships and morphological context was nearly impossible – until
now. Our Phenoptics™ research solutions enable you to better understand the relationships
between immune and other cells in the tumor and its microenvironment –
in situ,
in intact
FFPE sections, in
context.
So you can visualize and identify biomarkers, leading to better
understanding of disease mechanisms and stratification of cases for translational research.
Phenoptics research solutions: We’re looking inside for the next big cancer breakthrough.
For research use only.  Not for use in diagnostic procedures.
www.perkinelmer.com/phenoptics
pda.org/2018Micro
13th Annual PDA Conference
on Pharmaceutical Microbiology
The Future of Pharmaceutical Microbiology: Small World, Big Opportunities
Register
by August 4
and save up
to $600!
This popular Conference will take a look into the future of pharmaceutical microbiology, focusing on how industry
and global regulatory experts can work together to solve highly complex problems and develop novel, compliant,
and robust solutions to ensure products are of the highest quality for patients.
Hot topics will include:
“Ask the Experts” – back by popular demand!
Quality Management for the Microbiology Laboratory
Updates from the USP
Innovation in Pharmaceutical Microbiology
Be sure to visit the Exhibit Hall packed with the latest products and services, and take advantage of multiple
opportunities to network with experts and peers!
Select sessions will be simulcast with the PDA Europe Pharmaceutical Microbiology Conference!
To learn more and register, please visit pda.org/2018Micro
October 15-17, 2018 | Bethesda, MD
Exhibition: October 15-16
2018 PDA Endotoxins Workshop: October 17-18
Courses: October 18-19
#PDAMICRO
CONNECTING
PEOPLE
SCIENCE
AND
REGULATION
®
OCR (pmol/min)
Discover a Better Measure of
Immune Cell Activation
Detect immune cell activation in real time
with Agilent Seahorse XF Technology
What are you missing by waiting hours for immune cell activation results? Agilent Seahorse
XF technology detects immune cell activation after stimulation by measuring discrete
changes in cellular bioenergetics in live cells, in real time. Rapid detection opens a window
to the earliest events of immune cell activation, enabling researchers to identify changes in
activation kinetics, magnitude of the response, and duration.
- Capture the earliest events of activation within minutes
- Modulate activation with integrated compound injection ports
- Investigate immune cell metabolism through standardized assays and software
For Research Use Only.
Not for use in diagnostic procedures.
© Agilent Technologies, Inc. 2018
A
400
300
200
100
0
0
50
100 150
Time (min)
200
250
PMA
or Veh.
Rot/
AA
Human neutrophils
(4 x 104/well)
PMA
Vehicle
B
Neutrophil activation with
O
2
consumption (pmol)
2.0 x 104
injection of PMA after inhibition of
PMA
mitochondrial function.
1.5 x 104
Vehicle
1.0 x 104
0.5 x 104
To see more detail visit:
0
agilent.com/chem/
PMA
Vehicle
immunology
JUNE 2018
Contents
THE SCIENTIST
THE-SCIENTIST.COM
VOLUME 32 NUMBER 6
© ISTOCK.COM/1PHOTODIVA; © LUCY CONKLIN; © TAMI TOLPA
Features
ON THE COVER: © ISTOCK.COM/LORCEL
26
The Ancient Ones
Identification of new archaeal species
elucidates the domain’s unique biology
and its relationship to eukaryotes.
BY AMBER DANCE
34
Spotting Spillover
A step-by-step study of diseases that
jump species gives subtle clues about
future epidemics.
BY ASHLEY YEAGER
42
The Mystery of Caveolae
Researchers identified these abundant
invaginations on the surfaces of cells
more than half a century ago, but
questions about their function linger.
BY BEN NICHOLS
0 6. 201 8 | T H E S C IEN T IST
3
Zgłoś jeśli naruszono regulamin