Lab+Life Scientist - August-September_2018.pdf

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Publish with confidence
Around half of the money spent on protein-binding reagents globally is wasted
due to non-specific and inconsistent antibodies
1
. Simply offering replacements is
not good enough. Your results are too important for uncertainty.
Antibodies validated in knockout cell lines, which do not express the protein of
interest, provide a true negative control and guarantee specificity.
See how at:
www.abcam.com/validation
KO validated
using knockout-validated antibodies
1. Bradbury, A. and Plückthorn, A. 2015. Reproducibility: Standardize antibodies used in research. Nature. 518(7537), pp.27-29.
aug/sep 2018
Contents
06
AN EduCATION IN
EThICS
16
dr Ainsley Newson provides insights
on mitochondrial donation, targeted
testing and other ethical dilemmas.
40
CrISpr EdITINg mAy
BE LESS prECISE ThAN
prEVIOuSLy ThOughT
Scientists have discovered that
CrISpr/Cas9 gene editing can
cause greater genetic damage in
cells than was previously thought.
16
ImpACTFuL SCIENCE
Nobel prize-winning American
cell biologist sheds light on
extracellular vesicles (EVs),
exciting developments in the field
and challenges facing scientific
publishing.
43
KEy CANCEr-FIghTINg
gENE’S SECrET
wEApONS rEVEALEd
wEhI scientists have discovered
how the key cancer-preventing gene
p53 stops the development of blood
cancers.
27
22
VOyAgE TO AN
uNdErwATEr VOLCANO
Scientists have returned from an
expedition that took them 400 km
north-east of New Zealand.
Their goal? To drill into an active
underwater volcano.
50
dETAILEd prOTEIN dATA
ISOLATEd FrOm SINgLE
humAN CELLS
researchers have obtained a slew of
key information about proteins from
single human cells.
43
27
hOw A mAgNETISEd
wIrE ATTrACTS
TumOur CELLS
Scientists have used a magnetic
wire to capture free-floating tumour
cells in the blood.
55
KOALA gENOmE
SuCCESSFuLLy
SEquENCEd
Scientists have sequenced the full
koala genome, which may aid in the
treatment of disease and help inform
conservation efforts.
34
STOmATAL
dEVELOpmENT
International plant biologist
professor Keiko Torii sheds light
on stomatal development and the
future of plant science.
57
AgTA 2018
The AgTA conference is a must-
attend event for researchers and
industry representatives who work
with genomic technologies in a
variety of contexts including platform
development, medical genomics,
non-model systems etc.
55
READ ONLINE!
www.LabOnline.com.au | www.LifeScientist.com.au
This issue is available to read and download at
www.labonline.com.au/magazine
LAB+LIFE SCIENTIST - Aug/Sep 2018
|
3
editorial
© stock.adobe.com/au/chagpg
Australia may soon become the second country in
the world to legalise mitochondrial replacement
therapy, an IVF technique that could prevent
mitochondrial disease being passed on from
mother to child.
In this issue’s lead article, Dr Ainsley
Newson, Associate Professor of Bioethics at
Sydney Health Ethics, University of Sydney,
talks about mitochondrial donation, targeted
testing and other ethical dilemmas ahead of
the AACB AIMS 2018 Combined Scientific
Meeting. Dr Newson, who specialises in ethical
issues in genetics, genomics and emerging
biotechnologies, will be delivering the closing
plenary ‘The end of targeted testing? Should
patients routinely be given more information?’
at the 2018 combined scientific meeting of the
Australasian Association of Clinical Biochemists
(AACB) and the Australian Institute of Medical
Scientists (AIMS), to be held from 3–5 September
at ICC Sydney.
The AACB AIMS 2018 Combined Scientific
Meeting combines the AACB 56th Annual
Scientific Conference and the AIMS 47th
National Scientific Meeting. This year’s theme
is ‘Diagnosis to Cure’ with related topics to be
explored on each of the three days — on day
one the main topic will be metabolism; day two
will focus on cancer — molecular diagnosis
and classification, immunotherapies and drug
treatments; and on day three chronic diseases
such as diabetes, kidney disease, autoimmune
conditions and bleeding disorders will be
discussed.
This issue also features two speakers
presenting at ComBio2018, a major ASBMB
conference held each year, in association with
other organisations, to be held from 23–26
September 2018. This year’s ASBMB Grimwade
Keynote Plenary Lecture will be delivered by
Nobel prize-winning American cell biologist
Randy Wayne Schekman. Renowned plant
biologist Keiko Torii will deliver the Annals of
Botany Lecture at the major conference. To read
insights from these two experts, please visit pages
16 and 34, respectively.
We also report on an international team of
scientists’ two-month expedition — that took
them 400 km north-east of New Zealand — to
study an underwater volcano (page 22).
This issue features many other interesting
and insightful stories on a variety of topics.
Regards,
Mansi Gandhi
LLS@wfmedia.com.au
Mansi Gandhi
4
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LAB+LIFE SCIENTIST - Aug/Sep 2018
www.LabOnline.com.au | www.LifeScientist.com.au

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